|
KMID : 1377020150120010053
|
|
Tissue Engineering and Regenerative Medicine
2015 Volume.12 No. 1 p.53 ~ p.58
|
|
|
A modified rat tibia osteotomy model with proximal interlocked intramedullary nailing
|
|
Kwak Yoon-Hae
Yoo Je-Hyun
Kim Joo-Sung
Cho Hee-Yeon
Kweon Hae-Yong
Kang Dong-Chul
|
|
|
Abstract
|
|
|
|
The purpose of this study was to develop a rat tibia osteotomy model capable of providing more stability on osteotomy site using proximal interlocking intramedullary (IM) nailing with a modified Kirschner’s wire (K-wire). In group I, a standardized conventional osteotomy rat with 3-mm defect was fixed with 0.89-mm K-wire, while in group II we used pre-bended 0.89-mm K-wire which had a proximal hole for fixation with an interlocking pin. All 30 rats survived during experiment without sacrifices and group I had abrupt reduction of osteotomy gap on postoperative radiographs of day after surgery and maintained during rest first week after surgery. While sagittal angulation and gap reduction were progressed until postoperative 6 weeks in group I, most rats of group II showed consistent gap throughout the experiment period after surgery with statistical significance (p = 0.028). Initial sagittal angulation was excellent in group I (mean, 2.6 ± degrees) but it was not maintained until 6 weeks (mean, 26.73 ± degrees) but in group II initial sagittal angulation was severe than group I (18.27 degrees, p < 0.05) but angulation of group II was not progressed (23.6 degrees, p = 0.456). In conclusion, our modified rat tibia osteotomy model provide firm stability compared to previous models and it is inexpensive and reproducible without custom-made device or technical difficulty.
|
|
|
KEYWORD
|
|
|
Nonunion, Rat tibia osteotomy, Interlocking nail
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
   
|